Real Madrid, FC Barcelona and the other top five sides in LaLiga are all still present in the Copa del Rey, but some of them will now clash in the quarter-finals of the competition.
Defending champions Barcelona are also the record holders in the competition, having won the King's Cup 29 times so far.
Their bitter rivals Los Blancos, meanwhile, could win their 20th Copa del Rey trophy this year, having last won it in 2014.
With their massive 16-point gap to Barcelona in LaLiga, Real will be keen to focus on the Copa del Rey and UEFA Champions League in order to save their season.
The Spanish giants avoided each other in the quarter-final draw, which took place on Friday afternoon. The Catalan giants will face city rivals Espanyol, while Los Blancos will lock horns with Leganes.
Here is the complete Copa del Rey quarter-final draw:
Leganes vs Real Madrid
Espanyol vs FC Barcelona
Atletico Madrid vs Sevilla
Valencia vs Alaves
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International